反应详情

温度

50 °C

To a 50 ml volume three-necked flask, magnesium (cutting chip) (296 mg) and anhydrous tetrahydrofuran (6.75 ml) were added under a nitrogen atmosphere. Dibromoethane (95 mg) was added dropwise, and stirred at 50° C. for 30 minutes. To the mixture, 2-bromo-4-(4-chlorophenyl)-1-ethylbenzene (10-c) (3.0 g) dissolved in tetrahydrofuran (6.75 ml) was added dropwise over 10 minutes, stirred for 2.5 hours, and cooled to room temperature to give a solution of 5-(4-chlorophenyl)-2-ethylphenylmagnesium bromide in tetrahydrofuran.

1. additionwas added dropwise over 10 minutes
2. stirringstirred for 2.5 hours
3. temperaturecooled to room temperature