反应详情

1-(α-Bromoacetyl)naphthalene (5 g) and 1,1-dimethylurea (6 g) were stirred in anhydrous dimethylformamide (20 ml) at 105° C. overnight. The mixture was cooled, added to ethyl acetate, washed with sodium bicarbonate solution, water, brine, dried with sodium sulphate, filtered and evaporated in vacuo. The title compound was obtained (0.60 g; m.p. 30-32° C.) following silica gel column chromatography of the residue in dichloromethane.

1. temperatureThe mixture was cooled
2. washwashed with sodium bicarbonate solution, water, brine
3. dry with materialdried with sodium sulphate
4. filtrationfiltered
5. customevaporated in vacuo