Ammonia → HCID 67382945, compound

HRID 335884Notes

Reaction equation

HRID 335884 reaction equation
[NH3:1].CC(O)C.[F:6][C:7]([F:41])([CH2:13][C:14]1([OH:40])[C:27]2[CH:26]=[C:25]([O:28][CH2:29][C:30]([CH3:33])([CH3:32])[CH3:31])[CH:24]=[CH:23][C:22]=2[O:21][C:20]2[C:15]1=[CH:16][C:17]([C:34]1[CH:35]=[N:36][CH:37]=[N:38][CH:39]=1)=[CH:18][CH:19]=2)[C:8]([O:10]CC)=O>>[F:41][C:7]([F:6])([CH2:13][C:14]1([OH:40])[C:27]2[CH:26]=[C:25]([O:28][CH2:29][C:30]([CH3:31])([CH3:33])[CH3:32])[CH:24]=[CH:23][C:22]=2[O:21][C:20]2[C:15]1=[CH:16][C:17]([C:34]1[CH:39]=[N:38][CH:37]=[N:36][CH:35]=1)=[CH:18][CH:19]=2)[C:8]([NH2:1])=[O:10]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 3776IsopropanolHCID 67383774HCID 67383774, compound

Product 1

HCID 67382945HCID 67382945, compound

Procedure

Ammonia, as a 2 M solution in iPrOH (15 mL, 30.0 mmol), was added to ethyl 2,2-difluoro-3-(9-hydroxy-2-(neopentyloxy)-7-(pyrimidin-5-yl)-9H-xanthen-9-yl)propanoate (0.100 g, 0.201 mmol) at room temperature. After 30 minutes of stirring at RT the solution was concentrated to afford 2,2-difluoro-3-(9-hydroxy-2-(neopentyloxy)-7-(pyrimidin-5-yl)-9H-xanthen-9-yl)propanamide. M=470.3 [M+H].

Workup

  1. concentrationwas concentrated

Sources & evidence

ORD record
ord-9d2341d5ca6b4058875fca422d8bbfa8
Source dataset
uspto-grants-2014_11
Patent number
US08883782B2

Reaction notes

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