反应详情

温度

60 °C

1.5 g piperazine-1-carboxylic acid tert-butyl ester was added to 1.2 g 2-chlor-5-methoxy-pyrimidine and 2.2 mL triethylamine in 30 mL DMF. The reaction was stirred 6 days at 60° C. The solvent was removed and the residue was dissolved in dichlormethane and extracted with water. The organic layer was washed with a saturated sodium chloride solution and evaporated to give 957 mg desired product. Rt: 0.82 min (method E), (M+H)+: 295

1. customThe solvent was removed
2. dissolutionthe residue was dissolved in dichlormethane
3. extractionextracted with water
4. washThe organic layer was washed with a saturated sodium chloride solution
5. customevaporated