Potassium Carbonate → HCID 71667129, compound

HRID 336380Notes

Reaction equation

HRID 336380 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[NH:10][N:9]=2)=[CH:4][CH:3]=1.Br[CH2:21][C:22]([N:24]1[CH2:29][CH2:28][N:27]([C:30]2[N:35]=[CH:34][CH:33]=[CH:32][N:31]=2)[CH2:26][CH2:25]1)=[O:23].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[N:10]([CH2:21][C:22]([N:24]3[CH2:25][CH2:26][N:27]([C:30]4[N:31]=[CH:32][CH:33]=[CH:34][N:35]=4)[CH2:28][CH2:29]3)=[O:23])[N:9]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 636798462-Bromo-1-(4-pyrimidin-2-ylpiperazin-1-yl)ethanoneHCID 866865153,5-bis-(4-Fluoro-phenyl)-1H-(1,2,4)triazole

Product 1

HCID 71667129HCID 71667129, compoundYield 69.1%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

100 mg 3,5-bis-(4-fluoro-phenyl)-1H-(1,2,4)triazole, 111 mg 2-bromo-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanon and 237 mg potassiumcarbonat in 5 mL acetone was stirred 24 h at RT. The reaction was filtered and the filtrate was evaporated. The residue was crystallized with acetonitrile to yield 124 mg of the desired compound.

Workup

  1. filtrationThe reaction was filtered
  2. customthe filtrate was evaporated
  3. customThe residue was crystallized with acetonitrile

Sources & evidence

ORD record
ord-e32d1c6fcde94e279d860502355a0586
Source dataset
uspto-grants-2014_11
Patent number
US08889677B2

Reaction notes

Loading…