反应详情

温度

80 °C

4-(Pyridin-3-yl)oxy-1-nitrobenzene prepared in Step A was dissolved in the mixture of water (100 mL), tetrahydrofuran (100 mL) and methanol (100 mL). Iron powder (103 g, 1.84 mol) and ammonium chloride (99 g, 1.84 mol) were added thereto, and the mixture was stirred for 3 h at 80° C. using a mechanical stirrer. After completion of the reaction, the reaction mixture was filtered through a cellite, washed with methanol, and concentrated under reduced pressure. The solid thus obtained was filtered, washed with ether, and dried to give the title compound (17 g, Yield 36%).

1. customAfter completion of the reaction
2. filtrationthe reaction mixture was filtered through a cellite
3. washwashed with methanol
4. concentrationconcentrated under reduced pressure
5. customThe solid thus obtained
6. filtrationwas filtered
7. washwashed with ether
8. customdried