Hydrogen Bromide → HCID 68765009, compound

HRID 336562Notes

Reaction equation

HRID 336562 reaction equation
C(OC(=O)[NH:10][CH:11]1[C:13]2([CH2:18][CH2:17][N:16]([C:19]3[N:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[CH:21][N:20]=3)[CH2:15][CH2:14]2)[CH2:12]1)C1C=CC=CC=1.Br>C(O)(=O)C>[F:27][C:25]([F:26])([F:28])[C:23]1[CH:22]=[CH:21][N:20]=[C:19]([N:16]2[CH2:17][CH2:18][C:13]3([CH:11]([NH2:10])[CH2:12]3)[CH2:14][CH2:15]2)[N:24]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 131732017HCID 131732017, compound

Product 1

HCID 68765009HCID 68765009, compoundYield 1,001.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The process is performed according to the procedure described in Example 2 (step 2.5.). Starting with 0.86 g (2.13 mmol) of benzyl[6-(4-trifluoromethylpyrimidin-2-yl)-6-azaspiro[2.5]oct-1-yl]carbamate obtained in the preceding step and 3.74 mL (21.33 mmol) of a solution of 35% hydrobromic acid in acetic acid, and after basic extraction and uptake in diethyl ether, 0.32 g of product is obtained in the form of a white powder.

Sources & evidence

ORD record
ord-86b8264a808b44138f9fa6028bcf3043
Source dataset
uspto-grants-2014_11
Patent number
US08889702B2

Reaction notes

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