反应详情

A solution of potassium carbonate (24.9 g) and piperidine (130 mL) in 1:1 ethanol-water (130 mL) was treated with 3-bromopropan-1-ol (25.0 g). The resulting mixture was stirred vigorously for 20 h. Dichloromethane (200 mL) and water (50 mL) were added and the aqueous phase was extracted with dichloromethane (2×100 mL). The combined organic extracts were dried (magnesium sulfate) and evaporated in vacuo. Kugelrohr distillation of the residue (5-10 mm Hg, 120° C.) gave the title compound as a colorless oil (13.9 g).

1. extractionthe aqueous phase was extracted with dichloromethane (2×100 mL)
2. dry with materialThe combined organic extracts were dried (magnesium sulfate)
3. customevaporated in vacuo
4. distillationKugelrohr distillation of the residue (5-10 mm Hg, 120° C.)