反应详情

Hunig's Base (6.15 mL) was added to 5-bromo-4-fluoro-2-methylaniline (Example 318a, 3.59 g) in THF (50 mL) at room temperature followed by bromoacetonitrile (2.451 mL). The reaction was heated to reflux overnight. The reaction was cooled to room temperature and concentrated. 2N HCl and DCM were added. The organic layer was separated and dried (MgSO4) and concentrated to give the subtitle compound as a solid (6.61 g).

1. temperatureThe reaction was heated
2. temperatureto reflux overnight
3. concentrationconcentrated
4. addition2N HCl and DCM were added
5. customThe organic layer was separated
6. dry with materialdried (MgSO4)
7. concentrationconcentrated