Hydrochloric Acid → HCID 71060145, compound

HRID 337224Notes

Reaction equation

HRID 337224 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:33])[CH2:25][CH2:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)=[C:19]([Cl:34])[CH:18]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)(C)(C)C.Cl>O1CCOCC1>[NH2:7][CH:8]1[CH2:9][CH2:10][N:11]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:33])[CH2:25][CH2:26][C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)=[C:19]([Cl:34])[CH:18]=2)(=[O:15])=[O:16])[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71059991HCID 71059991, compound

Product 1

HCID 71060145HCID 71060145, compoundYield 113.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

{1-[3-Chloro-4-(3-phenyl-propionylamino)-benzenesulfonyl]-piperidin-4-yl}-carbamic acid tert-butyl ester (0.09 g, 0.1 mmol) was suspended in a 4M solution of HCl in Dioxane (5 ml). The resulting suspension was stirred at room temperature for 3 hours. After this time the solution was concentrated under vacuum to give the title compound (0.048 g, 99% yield) as a colourless oil which was taken on directly without further purification. Tr=1.71 min, m/z (ES+) (M+H)+ 422.

Workup

  1. concentrationAfter this time the solution was concentrated under vacuum

Sources & evidence

ORD record
ord-34df1506ad7247e9b9f242a04356d84e
Source dataset
uspto-grants-2014_11
Patent number
US08889716B2

Reaction notes

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