反应详情

To a solution of 2-(4-Hydroxyphenyl)acetonitrile (5 g, 37.5 mmol) and K2CO3 (6.74 g, 48.8 mmol) in dry DMF (20 ml) was added 2,6-Difluorobenzyl bromide (7.77 g, 37.5 mmol). The reaction mixture was stirred for 4 hours at room temperature and concentrated in vacuo. The crude residue was taken in EtOAc and washed with water and brine. The aqueous layer was washed one more time with EtOAc. The combined organic layer was dried over Na2SO4, filtered, and concentrated to provide the title compound as a white solid.

1. concentrationconcentrated in vacuo
2. washwashed with water and brine
3. washThe aqueous layer was washed one more time with EtOAc
4. dry with materialThe combined organic layer was dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated