Water → HCID 86703257, compound

HRID 337350Notes

Reaction equation

HRID 337350 reaction equation
[Cl:1][C:2]1[C:7]([CH2:8][CH3:9])=[CH:6][C:5]([OH:10])=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1.C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23].O>ClCCl>[CH3:21][S:22]([O:10][C:5]1[CH:6]=[C:7]([CH2:8][CH3:9])[C:2]([Cl:1])=[CH:3][C:4]=1[N+:11]([O-:13])=[O:12])(=[O:24])=[O:23]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 66648769HCID 66648769, compound

Product 1

HCID 86703257HCID 86703257, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

150 mg of 4-chloro-5-ethyl-2-nitrophenol was dissolved in 1.5 ml of dichloromethane, and 156 μl of triethylamine and 69 μl of methanesulfonylchloride were added at room temperature and stirred for 30 minutes. To the reaction mixture was added 50 ml of water, and extracted with 60 ml of ethyl acetate. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure to yield 200.7 mg of the title compound.

Workup

  1. extractionextracted with 60 ml of ethyl acetate
  2. dry with materialAfter the organic layer was dried over anhydrous magnesium sulfate
  3. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-f21e70f4059e4c3da1e7c7e4804e0463
Source dataset
uspto-grants-2014_11
Patent number
US08889727B2

Reaction notes

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