Potassium Carbonate → 1-[2-(4-Fluoro-2-methoxy-phenyl)-ethyl]-7-(pyrimidin-4-yl)-1H-imidazo[1,2-a]pyrimidin-5-one

HRID 33750Notes

Reaction equation

[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:8]=[C:9]3[NH:16][CH:15]=[CH:14][N:10]3[C:11](=[O:13])[CH:12]=2)=[N:3][CH:2]=1.C(=O)([O-])[O-].[K+].[K+].[F:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][CH2:31]OS(C)(=O)=O)=[C:26]([O:37][CH3:38])[CH:25]=1>CN(C)C=O>[F:23][C:24]1[CH:29]=[CH:28][C:27]([CH2:30][CH2:31][N:16]2[C:9]3=[N:8][C:7]([C:4]4[CH:5]=[CH:6][N:1]=[CH:2][N:3]=4)=[CH:12][C:11](=[O:13])[N:10]3[CH:14]=[CH:15]2)=[C:26]([O:37][CH3:38])[CH:25]=1

Participants

Conditions

Temperature: 70 °C

Procedure

A suspension of 0.4 g (1.88 mmol) of 7-(pyrimidin-4-yl)-1H-imidazo[1,2-a]pyrimidin-5-one in 10 ml of anhydrous N,N-dimethylformamide was treated with 337 mg (2.44 mmol) of potassium carbonate and the resulting mixture was heated at 70° C. for 30 min. 605 mg (2.44 mmol) of methanesulfonic acid 2-(4-fluoro-2-methoxy-phenyl)-ethyl ester was added and the reaction mixture was heated at 80° C. during 16 h.

Workup

temperaturethe reaction mixture was heated at 80° C. during 16 h.

Sources & evidence

ORD record: ord-d844a18f93fa4ba1b980b4f7b6882520
Source dataset: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07429663B2

Reaction notes

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