Trifluoroacetic acid → HCID 89962472, compound

HRID 337831Notes

Reaction equation

HRID 337831 reaction equation
COC1C=C(OC)C=CC=1C[N:6]([C:33]1[CH:38]=[CH:37][N:36]=[CH:35][N:34]=1)[S:7]([C:10]1[CH:15]=[C:14]([F:16])[C:13]([O:17][C@H:18]2[CH2:23][C:22]([CH3:25])([CH3:24])[CH2:21][CH2:20][C@@H:19]2[C:26]2[N:30]([CH3:31])[N:29]=[CH:28][CH:27]=2)=[CH:12][C:11]=1[F:32])(=[O:9])=[O:8].C([SiH](CC)CC)C.FC(F)(F)C(O)=O>ClCCl>[CH3:24][C:22]1([CH3:25])[CH2:23][C@H:18]([O:17][C:13]2[C:14]([F:16])=[CH:15][C:10]([S:7]([NH:6][C:33]3[CH:38]=[CH:37][N:36]=[CH:35][N:34]=3)(=[O:8])=[O:9])=[C:11]([F:32])[CH:12]=2)[C@@H:19]([C:26]2[N:30]([CH3:31])[N:29]=[CH:28][CH:27]=2)[CH2:20][CH2:21]1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 89961794HCID 89961794, compound

Product 1

HCID 89962472HCID 89962472, compoundYield 92.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 1b by using the N-(2,4-dimethoxybenzyl)-4-{[(1S*,2R*)-5,5-dimethyl-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}-2,5-difluoro-N-(pyrimidin-4-yl)benzenesulfonamide (100 mg, 0.159 mmol) prepared in Example 72e, triethylsilane (0.20 mL), trifluoroacetic acid (2.0 mL) and dichloromethane (2.0 mL), to yield the title compound (70 mg, 92%) as a colorless solid.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-7436287b7bb646729f161d66e18038ef
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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