Hydrochloric Acid → HCID 89962862, compound

HRID 337867Notes

Reaction equation

HRID 337867 reaction equation
[CH3:1][C:2]1([CH3:17])[CH2:10][C:5]2(OCC[O:6]2)[C:4]([C:11]2[N:15]([CH3:16])[N:14]=[CH:13][CH:12]=2)=[CH:3]1.Cl>C1COCC1>[CH3:1][C:2]1([CH3:17])[CH2:10][C:5](=[O:6])[C:4]([C:11]2[N:15]([CH3:16])[N:14]=[CH:13][CH:12]=2)=[CH:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89962694HCID 89962694, compound

Product 1

HCID 89962862HCID 89962862, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 67c by using the 5-(8,8-dimethyl-1,4-dioxaspiro[4.4]non-6-en-6-yl)-1-methyl-1H-pyrazole (1.07 g, 4.56 mmol) prepared in Example 93b, 2 M hydrochloric acid (5.0 mL) and THF (5.0 mL), to yield the title compound (780 mg, 90%) as a light brown solid.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-93fd330294ff481598d6196d6b329550
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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