Potassium Carbonate → HCID 89963531, compound

HRID 337917Notes

Reaction equation

HRID 337917 reaction equation
C([O:9][C@H:10]1[CH2:15][CH2:14][CH2:13][C:12]([F:17])([F:16])[C@@H:11]1[C:18]1[N:22]([CH3:23])[N:21]=[CH:20][CH:19]=1)(=O)C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>CO>[F:17][C:12]1([F:16])[CH2:13][CH2:14][CH2:15][C@H:10]([OH:9])[C@H:11]1[C:18]1[N:22]([CH3:23])[N:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 89962738HCID 89962738, compound

Product 1

HCID 89963531HCID 89963531, compoundYield 431.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 107e by using the (1S*,2R*)-3,3-difluoro-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl benzoate (206 mg, 0.643 mmol) prepared in Example 117c, potassium carbonate (270 mg, 1.95 mmol) and methanol (4.0 mL), to yield the title compound (600 mg, 43%) as a colorless solid.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-4c3a47be454e45f79a433d2c8f92c3ba
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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