HCID 89962762, compound → HCID 89962427, compound

HRID 337933Notes

Reaction equation

HRID 337933 reaction equation
[CH3:1][N:2]1[C:6]([C@:7]23[O:13][C@H:12]2[CH2:11][CH2:10][CH2:9][CH2:8]3)=[CH:5][CH:4]=[N:3]1>[Ni].C(O)(C)C>[CH3:1][N:2]1[C:6]([C@H:7]2[CH2:8][CH2:9][CH2:10][CH2:11][C@@H:12]2[OH:13])=[CH:5][CH:4]=[N:3]1

Participants

4

Reactant 1

HCID 89962762HCID 89962762, compound

Product 1

HCID 89962427HCID 89962427, compoundYield 28.5%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 3776IsopropanolSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 102c by using the 1-methyl-5-[(1S,6S)-7-oxabicyclo[4.1.0]hept-1-yl]-1H-pyrazole (0.21 g, 1.17 mmol) prepared in Example 123d, Raney nickel (2.0 g) and isopropanol (5.9 mL), to yield the title compound (0.060 g, 28%).

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-65a59f5547634cde8090e7c4a6321419
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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