p-Toluenesulfonic acid → HCID 89962122, compound

HRID 337968Notes

Reaction equation

HRID 337968 reaction equation
[F:1][C:2]1([F:17])[CH2:7][CH2:6][C:5]([C:9]2[CH:10]=[N:11][N:12]([CH2:14][O:15][CH3:16])[CH:13]=2)(O)[CH2:4][CH2:3]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[F:17][C:2]1([F:1])[CH2:7][CH2:6][C:5]([C:9]2[CH:10]=[N:11][N:12]([CH2:14][O:15][CH3:16])[CH:13]=2)=[CH:4][CH2:3]1

Participants

4

Reactant 2

HCID 6101p-Toluenesulfonic acidHCID 89962338HCID 89962338, compound

Product 1

HCID 89962122HCID 89962122, compoundYield 97.4%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 99b by using the 4,4-difluoro-1-[1-(methoxymethyl)-1H-pyrazol-4-yl]cyclohexanol (0.20 g, 0.81 mmol) prepared in Example 147a, p-toluenesulfonic acid (14 mg, 0.081 mmol) and toluene (5.0 mL), to yield the title compound (0.18 g, 97%) as a colorless oil.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-0ec6d00480604800bef0d9f2ea074c10
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

Loading…