Potassium Carbonate → HCID 89963376, compound

HRID 337992Notes

Reaction equation

HRID 337992 reaction equation
C([O:9][C@H:10]1[CH2:15][CH2:14][C:13]([F:17])([F:16])[CH2:12][C@@H:11]1[C:18]1[N:22]([CH2:23][O:24][CH2:25][CH2:26][O:27][CH3:28])[N:21]=[CH:20][CH:19]=1)(=O)C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>CO>[F:17][C:13]1([F:16])[CH2:14][CH2:15][C@H:10]([OH:9])[C@@H:11]([C:18]2[N:22]([CH2:23][O:24][CH2:25][CH2:26][O:27][CH3:28])[N:21]=[CH:20][CH:19]=2)[CH2:12]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 89962299HCID 89962299, compound

Product 1

HCID 89963376HCID 89963376, compoundYield 100.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 107e by using the (1S*,2R*)-4,4-difluoro-2-{1-[(2-methoxyethoxy)methyl]-1H-pyrazol-5-yl}cyclohexyl benzoate (547 mg, 1.39 mmol) prepared in Example 157b, potassium carbonate (19 mg, 0.139 mmol) and methanol (10 mL), to yield the title compound (404 mg, 99%) as a yellow oil.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-585de214735d4668991c238c457ff622
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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