Hydrochloric Acid → HCID 89963607, compound

HRID 337999Notes

Reaction equation

HRID 337999 reaction equation
[Cl:1][C:2]1[C:3]([O:19][C@@H:20]2[CH2:25][CH2:24][CH2:23][CH2:22][C@H:21]2[C:26]2[N:30](COCCOC)[N:29]=[CH:28][CH:27]=2)=[CH:4][C:5]([F:18])=[C:6]([S:8]([NH:11][C:12]2[CH:17]=[CH:16][N:15]=[CH:14][N:13]=2)(=[O:10])=[O:9])[CH:7]=1.Cl>CO>[Cl:1][C:2]1[C:3]([O:19][C@@H:20]2[CH2:25][CH2:24][CH2:23][CH2:22][C@H:21]2[C:26]2[NH:30][N:29]=[CH:28][CH:27]=2)=[CH:4][C:5]([F:18])=[C:6]([S:8]([NH:11][C:12]2[CH:17]=[CH:16][N:15]=[CH:14][N:13]=2)(=[O:10])=[O:9])[CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89962418HCID 89962418, compound

Product 1

HCID 89963607HCID 89963607, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 158e by using the 5-chloro-2-fluoro-4-{[(1R,2S)-2-{1-[(2-methoxyethoxy)methyl]-1H-pyrazol-5-yl}cyclohexyl]oxy}-N-(pyrimidin-4-yl)benzenesulfonamide (139 mg, 0.257 mmol) prepared in Example 159c, 6 M HCl (5.0 mL) and methanol (4.0 mL), to yield the title compound (101 mg, 73%) as a pale yellow solid.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-06c86ed5aad84d8bbe94768089307bf4
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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