Potassium Carbonate → HCID 89962701, compound

HRID 338016Notes

Reaction equation

HRID 338016 reaction equation
C([O:9][C@H:10]1[CH2:15][C@@H:14]([O:16][Si:17]([C:20]([CH3:23])([CH3:22])[CH3:21])([CH3:19])[CH3:18])[CH2:13][CH2:12][C@@H:11]1[C:24]1[N:28]([CH3:29])[N:27]=[CH:26][CH:25]=1)(=O)C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>CO>[Si:17]([O:16][C@@H:14]1[CH2:15][C@H:10]([OH:9])[C@@H:11]([C:24]2[N:28]([CH3:29])[N:27]=[CH:26][CH:25]=2)[CH2:12][CH2:13]1)([C:20]([CH3:23])([CH3:21])[CH3:22])([CH3:18])[CH3:19]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 89962785HCID 89962785, compound

Product 1

HCID 89962701HCID 89962701, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 162f by using the (1S*,2R*,5S*)-5-{[tert-butyl(dimethyl)silyl]oxy}-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl benzoate (327 mg, 1.09 mmol) prepared in Example 163e, potassium carbonate (301 mg, 2.18 mmol) and methanol (5.0 mL), to yield the title compound (207 mg, 87%) as a colorless oil.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-7bbdbd7ba4be487f95fcd06c04426505
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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