HCID 89962754, compound → HCID 89962599, compound

HRID 338030Notes

Reaction equation

HRID 338030 reaction equation
[CH3:1][N:2]1[C:6]([C@:7]23[CH2:16][CH2:15][CH2:14][CH2:13][C@H:8]2[O:9]C(=O)O3)=[CH:5][CH:4]=[N:3]1>[C].[Pd].C1COCC1>[CH3:1][N:2]1[C:6]([C@H:7]2[CH2:16][CH2:15][CH2:14][CH2:13][C@H:8]2[OH:9])=[CH:5][CH:4]=[N:3]1

Participants

4

Reactant 1

HCID 89962754HCID 89962754, compound

Product 1

HCID 89962599HCID 89962599, compoundYield 22%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 167b by using the (3aR,7aR)-3a-(1-methyl-1H-pyrazol-5-yl)hexahydro-1,3-benzodioxol-2-one (760 mg, 3.42 mmol) prepared in Example 168b, palladium carbon (10%; 760 mg) and THF (10 mL), to yield the title compound (133 mg, 22%) as a colorless oil.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-1b64a42225f64bfc8b8acfc63577d1f1
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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