反应详情

In an acetic acid solvent in the presence of sodium acetate (NaOAc) (3.0 eq.), a solution including 2-aminophenol (1.0 eq.) and 4-hydroxybenzaldehyde (1.0 eq.) was refluxed. After cooling, the reaction mixture was distributed between ethyl acetate and water, and an organic layer was dried, filtered, and evaporated. The residual was purified by silica gel column chromatography using hexane and ethyl acetate (4:1) to obtain a solid Compound 123.

1. temperaturewas refluxed
2. temperatureAfter cooling
3. customan organic layer was dried
4. filtrationfiltered
5. customevaporated
6. customThe residual was purified by silica gel column chromatography