反应详情

A solution of 7-bromo-8-fluoro-2-methylquinoline (0.15 g, 0.63 mmol), Pd(PPh3)4 (0.072 g, 0.063 mmol) and 0.5 M cyclopropylzinc(II) bromide (2.50 ml, 1.25 mmol) in THF was stirred at reflux for 12 hours. After cooling to ambient temperature, ethyl acetate (20 mL) and water (5 mL) were added. The organic layer was separated, washed with brine, dried (sodium sulfate), filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (hexane/ethyl acetate 2:1) to give 7-cyclopropyl-8-fluoro-2-methylquinoline (0.10 g, 80.3%) as a solid.

1. temperatureat reflux for 12 hours
2. customThe organic layer was separated
3. washwashed with brine
4. dry with materialdried (sodium sulfate)
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure
7. customThe residue was purified by flash chromatography on silica gel (hexane/ethyl acetate 2:1)