反应详情

A solution of (S)-propane-1,2-diol (1.9 mL, 26 mmol), tert-butyldimethylsilyl chloride (4.87 g, 32 mmol), and imidazole (4.5 g, 66 mmol) in anhydrous dimethylformamide (6.6 mL, 26 mmol) was allowed to stir at ambient temperature for 12 hours. The reaction mixture was poured into ethyl acetate (50 mL) and washed sequentially with saturated aqueous sodium bicarbonate (30 mL) and water (30 mL). The organic extract was dried over sodium sulfate, filtered and concentrated under reduced pressure to give the title compound (5.2 g, 104%) which was used without further purification.

1. washwashed sequentially with saturated aqueous sodium bicarbonate (30 mL) and water (30 mL)
2. extractionThe organic extract
3. dry with materialwas dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure