反应详情

温度

0 °C

To a solution of ethyl 3-methyl-3-(2-methylquinolin-8-yl)butanoate (0.66 g, 2.43 mmol) in THF (3 mL) was added 1.0 N LAH (3.65 mL, 3.65 mmol) in THF at 0° C. and stirred at 0° C. for 3 hours. Sodium sulfate decahydrate (2.0 g) was added and stirred at ambient temperature for 30 minutes. The solid was removed by filtration and washed with ethyl acetate (30 mL). The filtrate was concentrated under reduced pressure to give 3-methyl-3-(2-methylquinolin-8-yl)butan-1-ol (0.56 g, 100%) as a solid.

1. stirringstirred at ambient temperature for 30 minutes
2. customThe solid was removed by filtration
3. washwashed with ethyl acetate (30 mL)
4. concentrationThe filtrate was concentrated under reduced pressure