反应详情

To a stirred mixture of 2-methylquinolin-7-ol (400 mg, 2.51 mmol), Cs2CO3 (2.46 g, 7.54 mmol) and NMP (12 mL) was added bromoethane (0.563 mL, 7.54 mmol). The reaction mixture was stirred at ambient temperature overnight. The reaction was partitioned between ether and water. The aqueous layer was extracted with ether. The combined organic layers were washed with water and brine, dried and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (2:1 to 5:1 hexanes:EtOAc) to give 7-ethoxy-2-methylquinoline (416 mg, 88%).

1. customThe reaction was partitioned between ether and water
2. extractionThe aqueous layer was extracted with ether
3. washThe combined organic layers were washed with water and brine
4. customdried
5. concentrationconcentrated under reduced pressure
6. customThe residue was purified by flash chromatography on silica gel (2:1 to 5:1 hexanes:EtOAc)