反应详情

温度

80 °C

A solution of tert-butyl 4-formyl-3-hydroxybenzoate (1.2 g, 5.40 mmol) and potassium carbonate (1726 mg, 12.4 mmol) in DMF (17 ml) was admixed dropwise with ethyl bromoacetate (0.56 ml, 5.0 mmol) and stirred at 80° C. for 6 h. Then ethyl bromoacetate (0.28 ml, 2.5 mmol) was added again and the mixture was stirred at 80° C. overnight. After cooling to room temperature, the reaction mixture was added to ice-water and extracted with ethyl acetate. The organic phases were dried over sodium sulphate, filtered and concentrated to dryness under reduced pressure.

1. stirringthe mixture was stirred at 80° C. overnight
2. temperatureAfter cooling to room temperature
3. extractionextracted with ethyl acetate
4. dry with materialThe organic phases were dried over sodium sulphate
5. filtrationfiltered
6. concentrationconcentrated to dryness under reduced pressure