反应详情

To a solution of 4-[1-Methyl-3-(4-triisopropylsilanyloxymethyl-phenyl)-1H-pyrazol-4-yl]-pyridine (1.75 g) in THF (16.2 mL) was added TBAF (1.0M THF, 5.2 mL) and the reaction mixture stirred at ambient temperature under inert atmosphere for 1 h. The reaction mixture was poured into saturated sodium bicarbonate, extracted 3× with chloroform, dried magnesium sulfate filtered and concentration. Purification via MPLC biotage chromatography eluting with 2% methanol/0.5% saturated ammonium hydroxide/50% ethyl acetate/hexanes provided the title compound (920 mg, 84%). MS: (M+H m/z=266.1).

1. extractionextracted 3× with chloroform, dried magnesium sulfate
2. filtrationfiltered
3. concentrationconcentration
4. customPurification via MPLC biotage chromatography
5. washeluting with 2% methanol/0.5% saturated ammonium hydroxide/50% ethyl acetate/hexanes