Hydrochloric Acid → HCID 3284778, compound

HRID 339300Notes

Reaction equation

HRID 339300 reaction equation
[C:1]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:6]=[CH:5][C:4]([CH2:7][N:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[CH:3][CH:2]=1.Cl.C([O-])(O)=O.[Na+]>CO>[C:1]1([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:2]=[CH:3][C:4]([CH2:7][N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 68170489HCID 68170489, compound

Product 1

HCID 3284778HCID 3284778, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

0.35 g (1.0 mmol) of compound 51 was dissolved in 5 mL methanol and 0.5 mL 12 N HCl at room temperature. The mixture was stirred for 20 min and added to a solution of NaHCO3 and extracted 3× with EtOAc. The organic solution was dried over Na2SO4, filtered and concentrated in vacuo to give 0.25 g (100%) of 52.

Workup

  1. customat room temperature
  2. extractionextracted 3× with EtOAc
  3. dry with materialThe organic solution was dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-6b94cee34298493b82a6265b9ff29304
Source dataset
uspto-grants-2014_11
Patent number
US08894970B2

Reaction notes

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