Trifluoroacetic acid → HCID 67326385, compound

HRID 339483Notes

Reaction equation

HRID 339483 reaction equation
[CH2:1]([O:8][CH2:9][C@@H:10]([NH:22][C:23](=[O:53])[C@H:24]([NH:32][C:33]([C:35]1[CH:44]=[CH:43][C:38]([C:39]([O:41][CH3:42])=[O:40])=[C:37]([NH:45]C(OC(C)(C)C)=O)[CH:36]=1)=[O:34])[CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1)[C:11](=[O:21])[C:12]([NH:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:45][C:37]1[CH:36]=[C:35]([C:33]([NH:32][C@H:24]([CH2:25][CH:26]2[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]2)[C:23]([NH:22][CH:10]([CH2:9][O:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:11](=[O:21])[C:12]([NH:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[O:13])=[O:53])=[O:34])[CH:44]=[CH:43][C:38]=1[C:39]([O:41][CH3:42])=[O:40]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67326350HCID 67326350, compound

Product 1

HCID 67326385HCID 67326385, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 56 was dissolved in CH2Cl2, and TFA was added under 0° C. The solution was stirred for 30 min and then concentrated. Purification by chromatography (silica, 1/1: Hexane/EtOAc, Rf=0.3) afforded compound 21 as a white solid.

Workup

  1. concentrationconcentrated
  2. customPurification by chromatography (silica, 1/1: Hexane/EtOAc, Rf=0.3)

Sources & evidence

ORD record
ord-6ff950feadfb4d2aa073a81ed0a19910
Source dataset
uspto-grants-2014_11
Patent number
US08895497B2

Reaction notes

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