Stannous chloride dihydrate → HCID 67236560, compound

HRID 339501Notes

Reaction equation

HRID 339501 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:11][C:12]3[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:13]=3[N:14]=2)=[C:6]([C:21]([F:24])([F:23])[F:22])[CH:5]=1)([O-])=O.O.O.[Sn](Cl)Cl.C(Cl)Cl.CCOC(C)=O>CCO>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[S:11][C:12]3[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:13]=3[N:14]=2)=[C:6]([C:21]([F:23])([F:24])[F:22])[CH:5]=1

Participants

5

Reactant 3

HCID 61436Stannous chloride dihydrateHCID 21226138Dichloromethane ethylacetateHCID 67236586HCID 67236586, compound

Product 1

HCID 67236560HCID 67236560, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared as described in the Nitro Reduction section using 2-(4-nitro-2-trifluoromethylphenyl)-6-methoxybenzothiazole (0.6 g, 1.69 mmol) and tin (II) dichloride dihydrate (3.06 g, 13.56 mmol) in EtOH (35 ml) to give the title compound (0.51 g, 93%) as a colourless solid after work-up and flash chromatography (30:1 DCM/EtOAc).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-7f33165cf81e4f5c89cd6395b6638a98
Source dataset
uspto-grants-2014_11
Patent number
US08895313B2

Reaction notes

Loading…