Formaldehyde → HCID 67312034, compound

HRID 339517Notes

Reaction equation

HRID 339517 reaction equation
[C:1]([BH3-])#[N:2].[Na+].N[C:6]1[CH:31]=[CH:30][C:9]([C:10]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]3[S:20][C:21]4[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:22]=4[N:23]=3)=[CH:15][CH:14]=2)=[O:11])=[CH:8][CH:7]=1.[CH2:32]=O>CC(O)=O>[CH3:32][N:2]([CH3:1])[C:6]1[CH:31]=[CH:30][C:9]([C:10]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([C:19]3[S:20][C:21]4[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=[CH:24][C:22]=4[N:23]=3)=[CH:15][CH:14]=2)=[O:11])=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 5003444Sodium cyanoborohydrideHCID 67311799HCID 67311799, compound

Product 1

HCID 67312034HCID 67312034, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Prepared as described in the Amination section using sodium cyanoborohydride (67 mg, 1.06 mmol), 4-amino-N-[4-(6-methoxybenzothiazol-2-yl)-phenyl]-benzamide (80 mg, 0.213 mmol) and paraformaldehyde (64 mg, 2.13 mmol) in AcOH (2 ml) to give the title compound (49 mg, 57%) as colourless needles after recrystallisation from EtOH.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c6fb43770f1e441f8652b75588a21326
Source dataset
uspto-grants-2014_11
Patent number
US08895313B2

Reaction notes

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