Stannous chloride dihydrate → HCID 28325553, compound

HRID 339548Notes

Reaction equation

HRID 339548 reaction equation
[CH3:1][C:2]1[S:6][C:5]2=[N:7][C:8]([C:10]3[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=3)=[CH:9][N:4]2[CH:3]=1.O.O.[Sn](Cl)Cl.C(Cl)Cl.CCOC(C)=O>CCO>[CH3:1][C:2]1[S:6][C:5]2=[N:7][C:8]([C:10]3[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=3)=[CH:9][N:4]2[CH:3]=1

Participants

5

Reactant 3

HCID 61436Stannous chloride dihydrateHCID 868202Imidazo[2,1-b]thiazole, 2-methyl-6-(4-nitrophenyl)-HCID 21226138Dichloromethane ethylacetate

Product 1

HCID 28325553HCID 28325553, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared as described in the Nitro Reduction section using 2-methyl-6-(4-nitrophenyl) imidazo[2,1-b][1,3]thiazole (0.10 g, 0.386 mmol) and tin (II) chloride dihydrate (0.69 g, 3.09 mmol) in EtOH (15 ml) to give a pale orange solid (66 mg, 75%) after work-up and flash chromatography (1:1 DCM/EtOAc).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c78b93deb5d6428bb7fe4009722a037e
Source dataset
uspto-grants-2014_11
Patent number
US08895313B2

Reaction notes

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