反应详情

温度

80 °C

A mixture of 4-amino-6-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}pyrimidine (2.8 g), ethyl 5-chloromethyl-2-furancarboxylate (1.8 g), sodium hydrogencarbonate (1 g) and N,N-dimethylformamide (120 ml) was heated while stirring at 80° C. for 12 hours. The mixture thus obtained was concentrated under reduced pressure. To the resultant residue, water was added. After extraction was performed with ethyl acetate, an organic phase was dried over anhydrous sodium sulfate and evaporated. The resultant residue was purified by column chromatography to obtain a target substance (0.8 g). The target substance was subjected to e.g., proton nuclear magnetic resonance spectrometry (1H-NMR) and mass spectrometry (MS) and confirmed as the titled compound. Furthermore, MS measurement result is shown.

1. temperaturewas heated
2. customThe mixture thus obtained
3. concentrationwas concentrated under reduced pressure
4. additionTo the resultant residue, water was added
5. extractionAfter extraction
6. dry with materialan organic phase was dried over anhydrous sodium sulfate
7. customevaporated
8. customThe resultant residue was purified by column chromatography
9. customto obtain a target substance (0.8 g)