反应详情

To a solution of 4-chloro-5-phenoxypyrimidine (0.4 g, 1.9 mmol) described in JP-A-49-92080 and 4-trifluoromethylbenzylalcohol (0.36 g, 2.0 mmol) in dimethylacetamide (7 m) was added sodium hydride (0.093 g, 2.3 mmol) at 0° C., and the mixture was stirred at room temperature for 3 hrs. The reaction mixture was poured into ice water, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give 4-(4-trifluoromethylbenzyloxy)-5-phenoxypyrimidine (0.60 g).

1. extractionthe mixture was extracted with ethyl acetate
2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
3. concentrationthe solvent was concentrated under reduced pressure
4. customThe residue was purified by silica gel column chromatography