HRID339936

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID31297

Methanesulfonyl chloride

CH3ClO2S

结构：CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(CCCO)Cc3ccc(CC(=O)OC)cc3)c2n1

HCID57384852

未命名化合物

PRODUCTS

生成物

结构：CCCCOc1nc(N)c2[nH]c(=O)n(CCCN(CCCOS(C)(=O)=O)Cc3ccc(CC(=O)OC)cc3)c2n1

HCID57384593

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

The product from step (iii) (0.39 g) was dissolved in DCM (20 mL) and triethylamine (0.15 g) added, followed by addition of methanesulfonyl chloride (0.3 mL) and the mixture stirred for 5 hrs. The mixture was concentrated in vacuo to afford the subtitle compound as a crude product (0.45 g); MS multimode (+) 579.

WORKUP

后处理

concentrationThe mixture was concentrated in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a788f95360d54e969d199d1224bcdbcb
来源数据集: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08895570B2
来源说明: uspto-grants-2014_11

反应 SMILES

[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:36])[N:6]2[CH2:16][CH2:17][CH2:18][N:19]([CH2:24][C:25]1[CH:30]=[CH:29][C:28]([CH2:31][C:32]([O:34][CH3:35])=[O:33])=[CH:27][CH:26]=1)[CH2:20][CH2:21][CH2:22][OH:23].C(N(CC)CC)C.[CH3:44][S:45](Cl)(=[O:47])=[O:46]>C(Cl)Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:36])[N:6]2[CH2:16][CH2:17][CH2:18][N:19]([CH2:24][C:25]1[CH:26]=[CH:27][C:28]([CH2:31][C:32]([O:34][CH3:35])=[O:33])=[CH:29][CH:30]=1)[CH2:20][CH2:21][CH2:22][O:23][S:45]([CH3:44])(=[O:47])=[O:46]