反应详情

温度

5 °C

To a solution of 3-(6-amino-2-butoxy-8-methoxy-9H-purin-9-yl)propan-1-ol (18.0 g, 61.0 mmol) in NMP (146 g) was added triethylamine (9.3 g, 91.4 mmol) and the mixture stirred at 5° C. Methanesulfonylchloride (9.1 g, 79.2 mmol) was added dropwise to the solution and stirred at 5° C. for 30 min. Water (144 g) was added, the mixture stirred for 1 hr and the suspension filtered to give the subtitle compound as water wet cake, which was directly used in the next reaction. Yield 42.4 g as a crude product.

1. stirringstirred at 5° C. for 30 min
2. stirringthe mixture stirred for 1 hr
3. filtrationthe suspension filtered