反应详情

To 10 mL of a solution containing 360 mg of 3-naphthalen-2-yl-1-trityl-1H-pyrazolo[4,3-b]pyridine-5-carbonitrile obtained by Production example 15 in dichloromethane, 3 mL of trifluoroacetic acid was added at room temperature and stirred for 2 hours. The reaction solution was added with aqueous sodium hydrogen carbonate, extracted with ethyl acetate, washed with water, and dried over magnesium sulfate. After evaporating, the residue was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=3:1), to afford 180 mg of the title compound as a colorless powder.

1. extractionextracted with ethyl acetate
2. washwashed with water
3. dry with materialdried over magnesium sulfate
4. customAfter evaporating
5. customthe residue was purified
6. customseparated by silica gel column chromatography (ethyl acetate:n-hexane=3:1)