Triethylamine → 2-(2-Ethyl-5-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Temperature

110 °C

To a solution of 1-bromo-2-ethyl-5-fluoro-4-methoxy-benzene (Preparation 12, 18.0 g, 77.2 mmol) in dioxane (100 mL) were added SPhos (4.12 g, 10.0 mmol), 4,4,5,5-tetramethyl-1,3,2-dioxaborolane (14.8 g, 116 mmol) and triethylamine (10.7 mL, 77.2 mmol). The reaction mixture was degassed with nitrogen prior to the addition of dichlorobis(acetonitrile)palladium (II) (801 mg, 3.09 mmol). The reaction mixture was then heated at 110° C. for 18 hours, cooled to room temperature and filtered through a pad of Celite, washing with EtOAc. The solvent was removed in vacuo and the residue was redissolved in EtOAc (30 mL) and washed with water (30 mL). The organic layer was dried over sodium sulfate and concentrated in vacuo. The crude material was triturated with methanol and the resulting solid was collected by filtration to give the title compound as a beige solid (13.8 g) in a 64% yield.

1. customThe reaction mixture was degassed with nitrogen
2. temperaturecooled to room temperature
3. filtrationfiltered through a pad of Celite
4. washwashing with EtOAc
5. customThe solvent was removed in vacuo
6. dissolutionthe residue was redissolved in EtOAc (30 mL)
7. washwashed with water (30 mL)
8. dry with materialThe organic layer was dried over sodium sulfate
9. concentrationconcentrated in vacuo
10. customThe crude material was triturated with methanol
11. filtrationthe resulting solid was collected by filtration

ORD record

ord-a84cbdfea1bf432fb81ff563852174d7

Source dataset

uspto-grants-2014_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08895544B2