3-Bromopyridine → 6-Fluoro-3-[(E)-2-(pyridin-3-yl)-vinyl]-1-trityl-1H-indazole-5-carboxylic Acid Methyl Ester
Reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[F:14])[N:10]([C:15]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[N:9]=[C:8]2[CH:34]=[CH2:35])=[O:4].Br[C:37]1[CH:38]=[N:39][CH:40]=[CH:41][CH:42]=1>>[CH3:1][O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[F:14])[N:10]([C:15]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[N:9]=[C:8]2/[CH:34]=[CH:35]/[C:37]1[CH:38]=[N:39][CH:40]=[CH:41][CH:42]=1)=[O:4]Participants
3
Procedure
600 mg of 6-fluoro-1-trityl-3-vinyl-1H-indazole-5-carboxylic acid methyl ester and 190 μl of 3-bromopyridine were treated in the same manner as described in Example 124, to afford 75 mg of the title compound as a colorless powder.
Sources & evidence
- ORD record
- ord-726ed31139a1409ea2aa834f4cf22e91
- Source dataset
- uspto-grants-2008_09
- Patent number
- US07429609B2
Reaction notes
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