Hydrochloric Acid → HCID 59797049, compound

HRID 34043Notes

Reaction equation

HRID 34043 reaction equation
[CH3:1][O:2][C:3]1[C:11]([C:12](N)=[O:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5](/[CH:15]=[CH:16]/[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[N:6][NH:7]2.[OH-:23].[Li+].Cl>>[CH3:1][O:2][C:3]1[C:11]([C:12]([OH:23])=[O:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5](/[CH:15]=[CH:16]/[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[N:6][NH:7]2

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 59797368HCID 59797368, compound

Product 1

HCID 59797049HCID 59797049, compound

Conditions

Temperature
110 °C

Procedure

22 mg of 4-methoxy-3-(E)-styryl-1H-indazole-5-carboxylic acid amide was added to 3 mL of 4N lithium hydroxide aqueous solution, and stirred at 110° C. for 4 hours. After cooling on ice, the reaction solution was neutralized with 2N hydrochloric acid under ice cooling, and the precipitated crystals were collected by filtration and washed with water. This was then dried under reduced pressure, to afford 20 mg of the title compound as brown crude crystals.

Workup

  1. temperatureAfter cooling on ice
  2. filtrationthe precipitated crystals were collected by filtration
  3. washwashed with water
  4. customThis was then dried under reduced pressure

Sources & evidence

ORD record
ord-68273f5260b9449c8cffa603ab0d3dfb
Source dataset
uspto-grants-2008_09
Patent number
US07429609B2

Reaction notes

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