反应详情

温度

70 °C

Potassium carbonate (87 mg) and phenol (47 mg) were added to an N,N-dimethylacetamide (1 ml) solution containing 3-bromo-2-chloro-5-nitropyridine (100 mg), followed by stirring at 70° C. for 3 hours. Acetic acid palladium (20 mg) was added in a nitrogen atmosphere, followed by stirring at 100° C. for 3.5 hours. Water was added, followed by extraction with ethyl acetate. The resultant was washed with saturated saline and dried over anhydrous sodium sulfate. Subsequently, the solvent was distilled away under reduced pressure, hexane and ethyl acetate were added to the obtained residue, an insoluble precipitate was collected by filtration, and a light yellow solid of 3-nitrobenzofuro[2,3-b]pyridine (47.1 mg) was thus obtained.

1. stirringby stirring at 100° C. for 3.5 hours
2. extractionfollowed by extraction with ethyl acetate
3. washThe resultant was washed with saturated saline
4. dry with materialdried over anhydrous sodium sulfate
5. distillationSubsequently, the solvent was distilled away under reduced pressure, hexane and ethyl acetate
6. additionwere added to the obtained residue
7. filtrationan insoluble precipitate was collected by filtration