Iodine → HCID 178526495, compound

HRID 340497Notes

Reaction equation

HRID 340497 reaction equation
[OH-].[K+].[I:3]I.[N+:5]([C:8]1[CH:9]=[C:10]2[C:14](=[CH:15][CH:16]=1)[NH:13][N:12]=[CH:11]2)([O-:7])=[O:6].C(=O)([O-])O.[Na+]>CN(C=O)C>[I:3][C:11]1[C:10]2[C:14](=[CH:15][CH:16]=[C:8]([N+:5]([O-:7])=[O:6])[CH:9]=2)[NH:13][N:12]=1

Participants

6

Reactant 4

HCID 807IodineHCID 14797Potassium HydroxideHCID 215015-NitroindazoleHCID 516892Sodium Bicarbonate

Product 1

HCID 178526495HCID 178526495, compoundYield 77.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
65 °C

Procedure

Potassium hydroxide (6.45 g) and iodine (15.6 g) were added to a DMF (60 ml) solution containing 5-nitroindazole (5.0 g), followed by stirring at 65° C. for 1 hour. The reaction solution was adjusted to room temperature and poured into a saturated aqueous sodium hydrogen carbonate solution, a solid precipitate was collected by filtration, and a yellow solid of 3-iodo-5-nitro-1H-indazole (6.83 g) was thus obtained.

Workup

  1. customwas adjusted to room temperature
  2. filtrationa solid precipitate was collected by filtration

Sources & evidence

ORD record
ord-1b29927a43004fa2b263b8fe24dce9fc
Source dataset
uspto-grants-2014_11
Patent number
US08895585B2

Reaction notes

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