反应详情

To a solution of 5.8 g of 3-iodo-1H-pyrazolo[3,4-c]pyridine-5-carbonitrile in 70 mL of dichloromethane were added 13.1 mL of diisopropylethylamine, 2.4 g of tetra-n-butylammonium iodide and 12.0 g of trityl chloride at room temperature, and stirred at this temperature for a day. The solution was evaporated, diluted with ethyl acetate, washed successively with saturated ammonium chloride and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the crude product was purified and separated by silica gel column chromatography (ethyl acetate:n-hexane=1:10), to afford 5.2 g of the title compound as colorless crystals.

1. customThe solution was evaporated
2. additiondiluted with ethyl acetate
3. washwashed successively with saturated ammonium chloride and saturated brine
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe solvent was evaporated
6. customthe crude product was purified
7. customseparated by silica gel column chromatography (ethyl acetate:n-hexane=1:10)