反应详情

To a solution of 3-oxocyclohexane carboxylic acid (1.5 g, 10.6 mmol) in CH2Cl2 (35 mL) were added DMAP (0.129 g, 1.06 mmol), EDC (4.05 g, 21.1 mmol), and BnOH (1.2 mL, 11.6 mmol). The reaction was maintained at ambient temperature for 1 h. The reaction was further diluted with CH2Cl2, and then washed with saturated aqueous NaHCO3, followed by brine. The organic layer was separated, dried with MgSO4, filtered, and concentrated. The resulting crude product was used in the next step without further purification. LCMS: calculated for C14H16O3 232.28, observed m/e 233.1 (M+H)+ 255.0 (M+Na) (Rt 1.74/4 min).

1. washwashed with saturated aqueous NaHCO3
2. customThe organic layer was separated
3. dry with materialdried with MgSO4
4. filtrationfiltered
5. concentrationconcentrated
6. customThe resulting crude product was used in the next step without further purification
7. customm/e 233.1 (M+H)+ 255.0 (M+Na) (Rt 1.74/4 min)