Formic Acid → HCID 58319887, compound

HRID 340865Notes

Reaction equation

HRID 340865 reaction equation
[CH:1]([OH:3])=[O:2].C(N(CC)CC)C.Cl[CH2:12][C:13]([O:15][CH2:16][CH2:17][C:18]([O:21][C:22](=[O:25])[CH2:23]Cl)([CH3:20])[CH3:19])=[O:14].[C:26]([O:29]CC)(=[O:28])C>>[CH:1]([O:3][CH2:12][C:13]([O:15][CH2:16][CH2:17][C:18]([O:21][C:22](=[O:25])[CH2:23][O:29][CH:26]=[O:28])([CH3:20])[CH3:19])=[O:14])=[O:2]

Participants

5

Reactant 4

HCID 284Formic AcidHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 58319906HCID 58319906, compound

Product 1

HCID 58319887HCID 58319887, compound

Procedure

Formic acid (67) (0.921 g, 20 mmol) and triethylamine (2.226 g, 22 mmol) were combined and stirred for 30 minutes. Compound (101) (0.454 g, 1.8 mmol) was then added and stirred for three days. The solution was dissolved in 10 mL of ethyl acetate and the precipitate was filtered and washed with 10 mL, diethylether. The combined filtrate was then washed with brine and dried with sodium sulfate. The solvent was evaporated to get dark brown viscous oil.

Workup

  1. stirringstirred for three days
  2. filtrationthe precipitate was filtered
  3. washwashed with 10 mL, diethylether
  4. washThe combined filtrate was then washed with brine
  5. dry with materialdried with sodium sulfate
  6. customThe solvent was evaporated
  7. customto get dark brown viscous oil

Sources & evidence

ORD record
ord-c238ffcb4f4c4c8d9080eb677ad2baa5
Source dataset
uspto-grants-2014_11
Patent number
US08895691B2

Reaction notes

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