Formic Acid → HCID 58319881, compound

HRID 340868Notes

Reaction equation

HRID 340868 reaction equation
[CH:1]([OH:3])=[O:2].C(N(CC)CC)C.Cl[CH2:12][C:13]([O:15][C:16]([CH:19]1[CH2:24][CH2:23][C:22]([O:26][C:27](=[O:30])[CH2:28]Cl)([CH3:25])[CH2:21][CH2:20]1)([CH3:18])[CH3:17])=[O:14].[C:31]([O:34]CC)(=[O:33])C>>[CH:1]([O:3][CH2:12][C:13]([O:15][C:16]([CH:19]1[CH2:24][CH2:23][C:22]([O:26][C:27](=[O:30])[CH2:28][O:34][CH:31]=[O:33])([CH3:25])[CH2:21][CH2:20]1)([CH3:18])[CH3:17])=[O:14])=[O:2]

Participants

5

Reactant 4

HCID 284Formic AcidHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 58319886HCID 58319886, compound

Product 1

HCID 58319881HCID 58319881, compound

Procedure

Formic acid (67) (0.921 g, 20 mmol) and triethylamine (2.226 g, 22 mmol) were combined and stirred for 30 minutes. Compound (109) (0.623 g, 1.9 mmol) was then added and stirred for three days. The solution was dissolved in 10 mL of ethyl acetate and the precipitate was filtered and washed with 10 mL diethylether. The combined filtrate was then washed with brine and dried with sodium sulfate. The solvent was evaporated to get dark brown viscous oil.

Workup

  1. stirringstirred for three days
  2. filtrationthe precipitate was filtered
  3. washwashed with 10 mL diethylether
  4. washThe combined filtrate was then washed with brine
  5. dry with materialdried with sodium sulfate
  6. customThe solvent was evaporated
  7. customto get dark brown viscous oil

Sources & evidence

ORD record
ord-136609253c684f1fa44e05c58fb9567c
Source dataset
uspto-grants-2014_11
Patent number
US08895691B2

Reaction notes

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