Hydrochloric Acid → HCID 68595951, compound

HRID 341181Notes

Reaction equation

HRID 341181 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:31]=[CH:30][C:11]3[N:12]([C:15]4[CH:16]=[C:17]([NH:21][C:22]([NH:24][CH2:25][C:26]([F:29])([F:28])[F:27])=[O:23])[CH:18]=[CH:19][CH:20]=4)[CH:13]=[N:14][C:10]=3[CH:9]=2)=[CH:4][CH:3]=1.CCOC(C)=O.[ClH:38]>CO>[ClH:38].[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:31]=[CH:30][C:11]3[N:12]([C:15]4[CH:16]=[C:17]([NH:21][C:22]([NH:24][CH2:25][C:26]([F:27])([F:29])[F:28])=[O:23])[CH:18]=[CH:19][CH:20]=4)[CH:13]=[N:14][C:10]=3[CH:9]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 59320952HCID 59320952, compound

Product 1

HCID 68595951HCID 68595951, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 1-{3-[5-(4-Fluoro-phenyl)-benzoimidazol-1-yl]-phenyl}-3-(2,2,2-trifluoro-ethyl)-urea (Procedure O5) in MeOH was treated with an EtOAc solution of hydrogen chloride. The solid was collected and dried under vacuum.

Workup

  1. customThe solid was collected
  2. customdried under vacuum

Sources & evidence

ORD record
ord-48e29e89c80a4f80a9149788d9dd775e
Source dataset
uspto-grants-2014_11
Patent number
US08895745B2

Reaction notes

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