Hydrochloric Acid → HCID 57329642, compound

HRID 341276Notes

Reaction equation

HRID 341276 reaction equation
Cl.C([O:5][C:6]1[CH:11]=[CH:10][C:9]([C:12](=[O:23])[NH:13][C:14]2[S:15][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:17][N:18]=2)=[CH:8][CH:7]=1)(=O)C>O1CCCC1>[OH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([NH:13][C:14]2[S:15][C:16]([S:19]([CH3:22])(=[O:21])=[O:20])=[CH:17][N:18]=2)=[O:23])=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57329640HCID 57329640, compound

Product 1

HCID 57329642HCID 57329642, compoundYield 64.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2 M hydrochloric acid (45.0 mL) was added to a suspension of 78 (0.439 g, 1.29 mmol) in tetrahydrofuran (20.0 mL), and the suspension was warmed to reflux. The reaction became homogeneous upon heating. After refluxing for 4 hours, the reaction was allowed to cool to room temperature, and stood at room temperature overnight before the reaction was filtered. The filter pad was washed with water then dried in vacuo at 70° C. to give 80 (0.2489 g, 64.6%) as a white crystalline solid.

Workup

  1. temperaturethe suspension was warmed to reflux
  2. temperatureupon heating
  3. temperatureAfter refluxing for 4 hours
  4. filtrationwas filtered
  5. washThe filter pad was washed with water
  6. customthen dried in vacuo at 70° C.

Sources & evidence

ORD record
ord-9184852e3dfb4e169b4c82f65950b02e
Source dataset
uspto-grants-2014_11
Patent number
US08895752B2

Reaction notes

Loading…